曹威，博士，天津科技老员工物工程学院副研究员，硕士生导师。天津市“131”人才计划第三层次和天津市高校“青年后备人才支持计划”人选。微生物学会会员，中国生物发酵产业协会有机酸分会理事。
主讲课程
本科生：
[1] 微生物遗传与育种（双语）
[2] 微生物遗传与育种实验
[3] 基因工程实验
研究生：
代谢工程与合成生物学
主要教学研究及成果情况
先后发表教改论文1篇，参编教材1部。
[1] 曹威, 刘浩，李玉. 微生物遗传与育种实验课多维度考核方式初探, 科教导刊. 2021.
[2] 工业微生物分子生物学实验原理与技术.中国轻工业出版社, 2022
科研领域及方向
主要以丝状真菌为研究对象，利用合成生物学理念和技术，围绕生物基化学品发酵生产的通用底盘细胞构建开展基础和应用研究。
科研项目情况
[1] 高性能模块组装与高效整合；国家重点研发计划项目子课题2021.07-2024.06，子课题负责人
[2] 黑曲霉蛋白分泌突变体库构建；天津市合成生物技术创新能力提升行动，2019.10-2022.09，项目负责人
[3] 黑曲霉C4-二元羧酸转运蛋白编码基因的鉴定与功能研究；天津市自然科学基金青年项目，2018.10-2021.09，项目负责人
[4] 黑曲霉生物转化合成(R)-苯基乙酰基甲醇（PAC）机制研究；工业发酵微生物教育部重点实验室暨天津市工业微生物重点实验室（伟德BETVLCTOR）“生工英才培育计划”，2017.09-2020.12，项目负责人
[5] 兽疫链球菌谷氨酰胺代谢对透明质酸合成调控机理的研究；国家自然科学基金青年科学基金项目，2018.01-2020.12，项目负责人
主要学术成果
[1] Wei Cao, Licheng Zhang, Liu Wu, Mingyi Zhang, Jiao Liu, Zhoujie Xie and Hao Liu*, Identification and genetic characterization of mitochondrial citrate transporters in Aspergillus niger, Frontiers in Microbiology. 2022, 13:1009491.. Doi: 10.3389/fmicb.2022.1009491
[2] Wei Cao, Luwen Yan, Mengxin Li, Xinyuan Liu, Yongxue Xu, Zhoujie Xie, Hao Liu*, Identification and engineering a C4-dicarboxylate transporter for improvement of malic acid production in Aspergillus niger, Applied Microbiology and Biotechnology. 2020, 104(22): 9773–9783. doi:10.1007/s00253-020-10932-1.（2区TOP）
[3] Yongxue Xu, Lu Shan, Yutao Zhou, Zhoujie Xie, Andrew S. Ball, Wei Cao*, Hao Liu*. Development of a Cre-loxP-based genetic system in Aspergillus niger ATCC1015 and its application to construction of efficient organic acid-producing cell factories. Applied Microbiology and Biotechnology, 2019, 103(19): 8105–8114.
[4] Zhoujie Xie, Kai Meng, Xiaoli Yang, Jie Liu, Jie Yu, Chunyang Zheng, Wei Cao*, Hao Liu*. Identification of a Quorum Sensing System Regulating Capsule Polysaccharide Production and Biofilm Formation in Streptococcus zooepidemicus. Frontiers in cellular and infection microbiology, 2019. 9: 121.
[5] Xuewen Liu#, Wei Cao#, Shanshan Qin, Te Zhang, Junnian Zheng, Ying Dong, Pinghong Ming, Qian Cheng, Zheng Lu, Yang Guo, Baofu Zhang, Ying Liu*. Overexpression of CIP2A is associated with poor prognosis in multiple myeloma, Signal Transduction and Targeted Therapy, 2017, 2: e17013. (#, co-first author; *)
[6] Tingting Feng#, Wei Cao#, Wanxiang Shen, Liang Zhang, Xinsheng Gu, Yang Guo, Hsiang-i Tsai, Xuewen Liu, Jian Li, Jingxuan Zhang, Shan Li, Fuyun Wu, Ying Liu*, Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy, Oncotarget, 2016, 8(1): 329-344. (#, co-first author)
[7] Wei Cao#, Ying Liu#, Ran Zhang, Bo Zhang, Teng Wang, Xianbing Zhu, Lin Mei, Hongbo Chen, Hongling Zhang, and Pinghong Ming, Laiqiang Huang*, Homoharringtonine Induces Apoptosis and Inhibits STAT3 via IL-6/JAK1/STAT3 Signal Pathway in Gefitinib-Resistant Lung Cancer Cells, Scientific Reports, 2015, 5. (#, co-first author)
[8] Wei Cao, Xiaowei Zeng, Gan Liu, Zhen Li, Xiaobin Zeng, Lijun Wang, Laiqiang Huang, Si-Shen Feng, Lin Mei*, Porphine functionalized nanoparticles of star-shaped poly (ε-caprolactone)-b-D-α-tocopheryl polyethylene glycol 1000 succinate biodegradable copolymer for chemophotodynamic therapy on cervical cancer, Acta Biomaterialia, 2015, 26: 145-158.
[9] Ying Liu#, Wei Cao#, Bo Zhang, Yong-qiang Liu, Zhong-yuan Wang, Yan-ping Wu, Xian-jun Yu, Xu-dong Zhang, Ping-hong Ming, Guang-biao Zhou, Laiqiang Huang*, The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy, Scientific Reports, 2013, 3: 3089. (#, co-first author)
获奖情况
研究成果获得2018年天津市科技进步一等奖(2018JB-1-019-R8)。
联系方式
办公地点：天津经济技术开发区第十三大街9号天津科技老员工物工程学院
邮政编码：300457
Email：caowei040108@tust.edu.cn
