马倩,博士,副教授,硕士生导师。天津市“131”人才计划第三层次人选。天津微生物学会会员。
主讲课程:
本科生:生物工程概论
本科生:氨基酸工艺学
科研领域及方向
[1] 氨基酸及衍生物生产菌株构建
[2] 功能糖及衍生物生产菌株构建
[3] 发酵过程系统生物学解析
科研项目情况
[1] 主持国家重点研发计划(绿色生物制造)子课题项目,所属项目为:工业菌种基因组人工重排技术(2021YFC2100800),2021/7-2024/6,在研
[2] 主持国家自然科学基金青年项目:大肠杆菌中羟基四氢嘧啶可控合成体系的构建与调控研究(21808168),2019/1-2021/1,结题
[3] 主持天津市自然科学基金青年项目:谷氨酸棒杆菌分支链氨基酸合成途径中关键蛋白相互作用研究(17JCQNJC09500),2017/4-2020/3,结题
[4] 参与国家重点研发计划课题:高版本模式微生物底盘细胞系统集成与功能测试(2018YFA0900304),2019/07-2024/06,在研
[5] 参与国家自然科学基金面上项目:动态调节谷氨酸棒杆菌TCA循环调控4-羟基异亮氨酸高效合成的机制研究(32170049),2022/01/01-2025/12/31,在研
[6] 参与山东省重点研发计划(重大科技创新工程)项目:一步混菌发酵制备维生素C(2022CXGC010506),2022/2-2025/2,在研
主要学术成果
先后发表各类科研论文20余篇,授权发明专利6项。
发表的主要学术论文有:
[1] Ma Q, Xia L, Wu H, Zhuo M, et al. Metabolic engineering of Escherichia coli for efficient osmotic stress-free production of compatible solute hydroxyectoine. Biotechnology and Bioengineeing. 2022, 119(1): 89-101
[2] Ma Q, Sun Q, Tan M, Xia L, et al. Highly efficient production of N‑acetyl-glucosamine in Escherichia coli by appropriate catabolic division of labor in the utilization of mixed glycerol/glucose carbon sources. Journal of Agricultural and Food Chemistry, 2021, 69: 5966−5975
[3] Hao Y#, Ma Q#, Liu X, Fan X, et al. High-yield production of L-valine in engineered Escherichia coli by a novel two-stage fermentation. Metabolic Engineering, 2020, 62: 198-206
[4] Zhang Q#, Hou Z#, Ma Q#, Mo X, et al. CRISPRi-based dynamic control of carbon flow for efficient N‑acetyl glucosamine production and its metabolomic effects in Escherichia coli. Journal of Agricultural and Food Chemistry, 2020, 68: 3203−3213
[5] Ma Q, Bi Y, Wang E, Zhai B, et al. Integrated proteomic and metabolomic analysis of a reconstructed three‑species microbial consortium for one‑step fermentation of 2‑keto‑l‑gulonic acid, the precursor of vitamin C. Journal of Industrial Microbiology & Biotechnology, 2019, 46(1): 21-31
[6] Ma Q, Zhang Q, Xu Q, Zhang C, et al. Systems metabolic engineering strategies for the production of amino acids. Synthetic and Systems Biotechnology, 2017, 2: 87-96
[7] Ma Q, Zou Y, Lv Y, Song H, et al. Comparative proteomic analysis of experimental evolution of the Bacillus cereus-Ketogulonicigenium vulgare co-culture. Plos One, 2014, 9(3): e91789
[8] Ma Q, Wang J, Lu S, Lv Y, et al. Quantitative proteomic profiling reveals photosynthesis responsible for inoculum size dependent variation in Chlorella sorokiniana. Biotechnology and Bioengineering, 2013, 110(3): 773-784
[9] Ma Q, Zhang W, Zhang L, Qiao B, et al. Proteomic analysis of Ketogulonicigenium vulgare under glutathione reveals high demand for thiamin transport and antioxidant protection. Plos One, 2012, 7(2): e32156
[10] Ma Q, Zhou J, Zhang W, Meng X, et al. Integrated proteomic and metabolomic analysis of an artificial microbial community for two-step production of vitamin C. Plos One, 2011, 6(10): e26108
[11] Wang E, Ding M, Ma Q, et al. Reorganization of a synthetic microbial consortium for one-step vitamin C fermentation. Microbial Cell Factories, 2016, 15(1): 15-21
授权发明专利主要有:
[1] 马倩,孙全伟,谭淼,夏利,张颖,杨蒙雅,谢希贤,陈宁,徐庆阳,张成林,李燕军,范晓光. 一种产N-乙酰氨基葡萄糖的基因工程菌及其应用,2022.2.22,中国,ZL202011398296.9
[2] 马倩,谢希贤,陈宁,张权威,等,一种产生N-乙酰氨基葡萄糖的基因工程菌及其应用,2021.1.22,ZL201810503190.7
[3] 元英进,马倩,陆姝欢,吕亚金,一种微藻蛋白质组的分析方法,2014.4.16,ZL201210159134.9
[4] 元英进,马倩,张璐,检测谷胱甘肽作用于氧化葡糖杆菌过程中细胞内蛋白质变化的方法,2014.1.22,ZL202220346058.8
[5] 元英进,马倩,米造吉,谢萍,检测维生素C工业混菌发酵过程中细胞内蛋白质变化方法,2013.5.8,ZL202220065051.9
[6] 元英进,仪宏,王丽丽,周剑,马倩,薛佳,提高氧化葡糖杆菌产2-酮-L-古龙酸的方法,2011.6.1,ZL200910069697.7
联系方式
办公地点:天津经济技术开发区第十三大街29号天津科技老员工物工程学院
邮政编码:300457
办公电话:022-60601251
传 真:022-60602298
Email:qianma1987@tust.edu.cn