陈保送,博士,天津科技老员工物工程学院讲师、内聘副教授。本科毕业于西北农林科技大学制药工程专业,博士/博士后工作于中国科学院微生物研究所。中国医药生物技术协会酶与发酵工程专业委员会委员,中国菌物学会茯苓产业分会理事。
主讲课程
无
主要教学研究及成果情况
主编或参编教材或专著2部。
[1] 《真菌进化生物学-第十章 真菌进化生物学应用》科学出版社2022年3月
[2] 《天然药物化学》(数字课程编委) 高等教育出版社 2024年(待出版)
科研领域及方向
科研方向围绕“真菌活性次级代谢产物结构、功能与应用”这个关键的科学问题,深入挖掘真菌活性成分,开展活性评价及高值化产品研发。
[1]食药用真菌活性物质及高值化应用
[2]特殊生境微生物活性成分挖掘及应用
科研项目情况
[1] 国家自然科学基金青年科学基金项目,82204257,抗阿尔茨海默病活性鸟巢烷二萜高效挖掘,2023-01-01至2025-12-31,主持;
[2] 中国博士后科学基金面上项目,2021M703447,基于组合生物合成新结构鸟巢烷二萜的发现及抗阿尔兹海默病活性评价,2021-2023,主持
主要学术成果
先后以第一作者(共同)/共同通讯作者发表研究论文16篇,授权发明专利3项(PCT专利1项)。发表的主要学术论文有:
[1]. Baosong Chen, Jinjin Zhang, Junjie Han, Ruilin Zhao, Li ao*, Ying Huang, Hongwei Liu *. Lanostane triterpenoids with glucose-uptake-stimulatory activity from peels of the cultivated edible mushroom Wolfiporia cocos. Journal of Agricultural and Food Chemistry, 2019, 67, 7348-7364. (第一作者)
[2]. Baosong Chen1, Junjie Han1, Mengmeng Wang, Huanqin Dai, Jinjin Zhang, Lei Cai, Shenglong Wei, Xue Zhang, Hongwei Liu *. Amplisins A–E, chromone methide polymers with hypoglycemic activity from a new fungicolous fungus Amplistroma fungicola. Organic Chemistry Frontiers, 2020, 7, 2761-2769. (第一作者)
[3]. Baosong Chen1, Jinghan Lin1, Ao Xu, Dan Yu, Dorji Phurbu, Huanqin Dai, Yi Li, Hongwei Liu. Glyceroglycolipids from the solid culture of Ophiocordyceps sinensis strain LY34 isolated from Tibet of China. Mycology, 2022, 22;13(3):185-194. (第一作者)
[4]. Baosong Chen1, Yue Wang1, Feng Xie, Hongwei Liu, Huanqin Dai. Identification of siderophores blocking infection of Pseudomonas aeruginosa from Kitasatospora sp. LS1784. Journal of Antibiotics, 2024, 77(1):4-12. (第一作者)
[5]. Baosong Chen, Junjie Han, Li Bao, Wenzhao Wang, Ke Ma, Hongwei Liu *. Identification and α-glucosidase inhibitory activity of meroterpenoids from Hericium erinaceus. Planta Medica, 2020, 86, 571-578. (第一作者)
[6]. Baosong Chen, Sixian Wang, Gaoqiang Liu, Li Bao, Ying Huang, Hongwei Liu *. Anti-inflammatory diterpenes and steroids from peels of the cultivated edible mushroom Wolfiporia cocos. Phytochemistry letters, 2020, 36, 11-16. (第一作者)
[7]. Baosong Chen1, Erwei Li1, Li Liu, Mingfang Liao, Zhaoxiang Zhu, Wenying Zhuang, Li Bao, Hongwei Liu*. Botryane sesquiterpenoids, cyclopentadepsipeptides, xanthones, and trichothecenes from Trichoderma oligosporum. Planta Medica, 2018, 84, 1055-1063. (第一作者)
[8]. Baosong Chen1, Jin Tian1, Jinjin Zhang, Kai Wang, Li Liu, Bo Yang, Li Bao, Hongwei Liu*. Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMGs reductase, aldose reductase and alpha-glucosidase. Fitoterapia, 2017, 120, 6-16. (第一作者)
[9]. Haifeng Wang, Rui Zhang, Ben Ma, Wenzhao Wang, Chong Yu, Junjie Han, Lingjuan Zhu, Xue Zhang, Huanqin Dai, Hongwei Liu,* Baosong Chen*. Japonamides A and B, two new cyclohexadepsipeptides from the marine-sponge-derived fungus Aspergillus japonicus and their synergistic antifungal activities. Journal of Fungi, 2022, 8(10), 1058. (通讯作者)
[10]. Jinjin Zhang 1, Baosong Chen 1, Jack Liang, Junjie Han, Liwei Zhou, Ruilin Zhao, Hongwei Liu*, and Huanqin Dai *. Lanostane Triterpenoids with PTP1B Inhibitory and Glucose-Uptake Stimulatory Activities from Mushroom Fomitopsis pinicola Collected in North America. Journal of Agricultural and Food Chemistry, 2020, 68, 10036–10049. (共同第一作者)
[11]. Wang Dong1, Baosong Chen1, Rui Zhang, Huanqin Dai, Junjie Han, Yongzhong Lu, Qi Zhao, Xingzhong Liu, Hongwei Liu, Jingzu Sun. Identification and characterization of peptaibols as the causing agents of Pseudodiploöspora longispora infecting the edible mushroom Morchella. Journal of Agricultural and Food Chemistry, 2023, 71, 47, 18385–18394. (共同第一作者)
[12]. Junjie Han1, Baosong Chen1, Rui Zhang, Jinjin Zhang, Huanqin Dai, Tao Wang, Jingzu Sun, Guoliang Zhu, Wei Li, Erwei Li, Xueting Liu, Wenbing Yin, Hongwei Liu. Exploring verrucosidin derivatives with glucose-uptake-stimulatory activity from Penicillium cellarum using MS/MS-based molecular networking, Journal of Fungi, 2022, 8(2), 143. (共同第一作者)
[13]. Jinjin Zhang1, Baosong Chen1, Huanqin Dai, Jinwei Ren, Liwei Zhou, Shenghua Wu, Hongwei Liu. Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang. Chinese Journal of Natural Medicines, 2021, 19(9):693-699. (共同第一作者)
[14]. Buddha Bahadur Basnet 1, Baosong Chen 1, Yerlan Melsuly Suleimen, Ke Ma, Shouyu Guo, Li Bao, Ying Huang, Hongwei Liu *. Cytotoxic secondary metabolites from the endolichenic fungus Hypoxylon fuscum. Planta Medica, 2019, 85, 1088-1097. Planta Medica, 2018, 84, 1055-1063. (共同第一作者)
[15]. Buddha Bahadur Basnet 1, Li Liu 1, Baosong Chen 1, Yerlan Melsuly Suleimen, Haiyang Yu, Shouyu Guo, Li Bao, Jinwei Ren, Hongwei Liu*. Four new cytotoxic arborinane type triterpenes from the endolichenic fungus Myrothecium inundatum. Planta Medica, 2019, 85, 701-707. Planta Medica, 2018, 84, 1055-1063. (共同第一作者)
[16]. 汪锴,陈保送1,宝丽,等.猴头菌属药用真菌活性次级代谢产物研究概况.菌物学报,2015,34(04):553-568. (共同第一作者)
授权发明专利主要有:
[1]刘宏伟,马兵,杨波,宝丽,陈保送. 灵芝杂萜化合物、其药用组合物及其应用. 专利号:ZL201710286626.7
[2]刘宏伟,宝丽,陈保送,张金金. 一种茯苓皮三萜组合物的制备方法及其应用. 专利号:ZL201910092966.5
[3]刘宏伟,宝丽,陈保送,张金金. 一种茯苓皮三萜组合物的制备方法及其应用.国际申请号:PCT/CN2019/128086
获奖情况
北京市优秀毕业生,中国科学院优秀毕业生
联系方式
办公地点:天津经济技术开发区第十三大街29号天津科技老员工物工程学院
邮政编码:300457
办公电话:18510854810
Email: chenbs@tust.edu.cn