于爱群，博士，天津科技老员工物工程学院教授，博士生导师。入选天津市海外高层次人才计划、伟德BETVLCTOR海河学者培育计划、天津青年科技工作者协会会员。
主讲课程：
本科生：酵母工艺学、酿酒技术概论、生物科技认识实习
研究生：科技论文写作
出版专著情况：
[1] 工业微生物分子生物学实验原理与技术，中国轻工业出版社，2022年7月出版，张成林主编，于爱群参编第10章。
科研领域及方向：
[1] 酵母菌代谢调控与分子育种
[2] 酵母菌合成生物学及绿色生物制造
[3] 现代酿造技术
科研项目情况：
作为项目负责人先后主持各类科研项目10项。
[1] 国家重点研发计划子课题：基于生化反应代谢规律全新创建生物合成途径
[2] 天津市应用基础研究项目：代谢途径亚细胞区室化调控解脂耶氏酵母绿色高效合成倍半萜化合物及其机制研究
[3] 天津市自然科学基金绿色通道项目：代谢工程改造解脂耶氏酵母生物合成功能性倍半萜化合物研究
[4] 天津市教委科研计划项目重点项目：代谢工程改造解脂耶氏酵母生物合成功能性单萜化合物
[5] 伟德BETVLCTOR海河学者培育计划引进人才基金：代谢工程改造解脂耶氏酵母生产天然活性单萜
[6] 天津市高层次人才计划基金：代谢工程改造非常规酵母底盘生产高值化学品的研究
[7] 企业横向课题：人工甜味剂生产菌株的升级改造
[8] 企业横向课题：非常规酵母底盘合成麦角硫因的途径组装及适配策略研究
[9] 企业横向课题：多肽类药物生产菌株的开发
[10] 企业横向课题：木薯渣水解液发酵产酒精工艺优化
主要学术成果：
截止目前，本人已经在酵母菌代谢工程和合成生物学改造的研究领域内取得了诸多创新性科研成果，已在Biotechnology Advances、Metabolic Engineering、Green Chemistry、ACS Sustainable Chemistry & Engineering、ACS Synthetic Biology等生物工程领域高水平期刊上共发表34篇通讯作者/第一作者论文，单篇最高SCI影响因子为16（2篇）；授权/申请中国发明专利7项。
（1）代表性学术论文：
[1] Kun Zhu, Jing Kong, Baixiang Zhao, Lanxin Rong, Shiqi Liu, Zhihui Lu, Cuiying Zhang, Dongguang Xiao, Krithi Pushpanathan, Jee Loon Foo*, Adison Wong*, Aiqun Yu*. Metabolic engineering of microbes for monoterpenoid production. Biotechnology Advances, 2021, 53: 107837. (IF: 16)
[2] Jian Li, Lanxin Rong, Yu Zhao, Shenglong Li, Cuiying Zhang, Dongguang Xiao, Jee Loon Foo*, Aiqun Yu*. Next-generation metabolic engineering of non-conventional microbial cell factories for carboxylic acid platform chemicals. Biotechnology Advances, 2020, 43: 107605. (IF: 16)
[3] Baixiang Zhao, Yahui Zhang, Yaping Wang, Zhihui Lu, Lin Miao, Shuhui Wang, Zhuo Li, Xu Sun, Yuqing Han, Sicheng He, Ziyuan Zhang, Dongguang Xiao, Cuiying Zhang*, Jee Loon Foo*, Adison Wong*, Aiqun Yu*. Biosynthesis of α‑bisabolene from low-cost renewable feedstocks by peroxisome engineering and systems metabolic engineering of the yeast Yarrowia lipolytica. Green Chemistry, 2023, 25(20): 8145-8159. (IF: 9.8)
[4] Kun Zhu, Baixiang Zhao, Yahui Zhang, Jing Kong, Lanxin Rong, Shiqi Liu, Yaping Wang, Cuiying Zhang, Dongguang Xiao, Jee Loon Foo*, Aiqun Yu*. Mitochondrial engineering of Yarrowia lipolytica for sustainable production of α‑bisabolene from waste cooking oil. ACS Sustainable Chemistry & Engineering, 2022, 10(29): 9644-9653. (IF: 8.4)
[5] Aiqun Yu, Nina Kurniasih Pratomo Juwono, Jee Loon Foo, Susanna Su Jan Leong, Matthew Wook Chang*. Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids. Metabolic Engineering, 2016, 34: 36-43. (IF: 8.4)
[6] Jing Kong, Lin Miao, Zhihui Lu, Shuhui Wang, Baixiang Zhao, Cuiying Zhang, Dongguang Xiao, Desmond Teo, Susanna Su Jan Leong, Adison Wong*, Aiqun Yu*. Enhanced production of amyrin in Yarrowia lipolytica using a combinatorial protein and metabolic engineering approach. Microbial Cell Factories, 2022, 21: 86. (IF: 6.4)
[7] Aiqun Yu*, Yakun Zhao, Yaru Pang, Zhihui Hu, Cuiying Zhang, Dongguang Xiao, Matthew Wook Chang, Susanna Su Jan Leong. An oleaginous yeast platform for renewable 1-butanol synthesis based on a heterologous CoA dependent pathway and an endogenous pathway. Microbial Cell Factories, 2018, 17: 166. (IF: 6.4)
[8] Yu Zhao, Shiqi Liu, Zhihui Lu, Baixiang Zhao, Shuhui Wang, Cuiying Zhang, Dongguang Xiao, Jee Loon Foo, Aiqun Yu*. Hybrid promoter engineering strategies in Yarrowia lipolytica: isoamyl alcohol production as a test study. Biotechnology for Biofuels, 2021, 14: 149. (IF: 6.3)
[9] Yaru Pang, Yakun Zhao, Shenglong Li, Yu Zhao, Jian Li, Zhihui Hu, Cuiying Zhang, Dongguang Xiao, Aiqun Yu*. Engineering the oleaginous yeast Yarrowia lipolytica to produce limonene from waste cooking oil. Biotechnology for Biofuels, 2019, 12: 241. (IF: 6.3)
[10] Zhihui Lu, Yaping Wang, Zhuo Li, Yahui Zhang, Sicheng He, Ziyuan Zhang, Susanna Su Jan Leong, Adison Wong*, Cuiying Zhang*, Aiqun Yu*. Combining metabolic engineering and lipid droplet storage engineering for improved α-bisabolene production in Yarrowia lipolytica. Journal of Agricultural and Food Chemistry, 2023, 71(30): 11534-11543. (IF: 6.1)
[11] Yakun Zhao, Kun Zhu, Jian Li, Yu Zhao, Shenglong Li, Cuiying Zhang, Dongguang Xiao, Aiqun Yu*. High-efficiency production of bisabolene from waste
cooking oil by metabolically engineered Yarrowia lipolytica. Microbial Biotechnology, 2021, 14(6): 2497-2513. (IF: 5.7)
[12] Lanxin Rong, Lin Miao, Shuhui Wang, Yaping Wang, Shiqi Liu, Zhihui Lu,
Baixiang Zhao, Cuiying Zhang, Dongguang Xiao, Krithi Pushpanathan, Adison Wong*, Aiqun Yu*. Engineering Yarrowia lipolytica to produce itaconic acid from waste cooking oil. Frontiers in Bioengineering and Biotechnology, 2022, 10: 888869. (IF: 5.7)
[13] Aiqun Yu, Nina Kurniasih Pratomo Juwono, Susanna Su Jan Leong, Matthew Wook Chang*. Production of fatty acid-derived valuable chemicals in synthetic microbes. Frontiers in Bioengineering and Biotechnology, 2014, 2: 78. (IF: 5.7)
[14] Jian Li, Kun Zhu, Lin Miao, Lanxin Rong, Yu Zhao, Shenglong Li, Lijuan Ma, Jianxun Li, Cuiying Zhang, Dongguang Xiao, Jee Loon Foo, Aiqun Yu*. Simultaneous improvement of limonene production and tolerance in Yarrowia lipolytica through tolerance engineering and evolutionary engineering. ACS Synthetic Biology, 2021, 10(4): 884-896. (IF: 4.7)
[15] Shenglong Li, Lanxin Rong, Shuhui Wang, Shiqi Liu, Zhihui Lu, Lin Miao, Baixiang Zhao, Cuiying Zhang, Dongguang Xiao, Krithi Pushpanathan, Adison Wong*, Aiqun Yu*. Enhanced limonene production by metabolically engineered Yarrowia lipolytica from cheap carbon sources. Chemical Engineering Science, 2022, 249: 117342. (IF: 4.7)
[16] Aiqun Yu*, Yu Zhao, Jian Li, Shenglong Li, Yaru Pang, Yakun Zhao, Cuiying Zhang, Dongguang Xiao. Sustainable production of FAEE biodiesel using the oleaginous yeast Yarrowia lipolytica. MicrobiologyOpen, 2020, 9(7): e1051. (IF: 3.4)
[17] Tee-Kheang Ng#, Aiqun Yu#, Hua Ling, Nina Kurniasih Pratomo Juwono, Won Jae Choi, Susanna Su Jan Leong, Matthew Wook Chang*. Engineering Yarrowia lipolytica towards food waste bioremediation: Production of fatty acid ethyl esters from vegetable cooking oil. Journal of Bioscience and Bioengineering, 2020, 129(1): 31-40. (IF: 2.8)
[18] Aiqun Yu, Jianchun Zhu, Biao Zhang, Laijun Xing, Mingchun Li*. Knockout of fatty acid desaturase genes in Pichia pastoris GS115 and its effect on the fatty acid biosynthesis and physio-logical consequences. Archives of Microbiology, 2012, 194(12): 1023-1032. (IF:2.8)
[19] Aiqun Yu, Jianchun Zhu, Biao Zhang, Laijun Xing, Mingchun Li*. Effects of different carbon sources on the growth, fatty acids production, and expression of three desaturase genes of Mortierella alpina ATCC 16266. Current Microbiology, 2011, 62(5): 1617-1622. (IF: 2.6)
[20] Aiqun Yu, Tonglei Shi, Biao Zhang, Laijun Xing, Mingchun Li*. Transcriptional regulation of desaturase genes in Pichia pastoris GS115. Lipids, 2012, 47(11): 1099-1108. (IF: 1.9)
[21] Aiqun Yu, Nina Kurniasih Pratomo Juwono, Tee-Kheang Ng, Hua Ling, Han-Saem Cho, Su-sanna Su Jan Leong, Matthew Wook Chang*. Genetic engineering of an unconventional yeast for renewable biofuel and biochemical production. Jove-Journal of Visualized Experiments, 2016, 115: e54371. (IF: 1.2)
[22] 荣兰新, 刘士琦, 朱坤, 孔婧, 苗琳, 王淑慧, 肖冬光, 于爱群*. 代谢工程改造解脂耶氏酵母合成羧酸的研究进展. 生物工程学报, 2022, 38(4): 1360-1372.
[23] 李建, 孔婧, 李圣龙, 赵禹, 赵雅坤, 肖冬光, 于爱群*. 适应性实验室进化技术在微生物育种中的应用进展. 生物工程学报, 2021, 37(1): 130-141.
[24] 庞亚如, 胡智慧, 肖冬光, 于爱群*. 柠檬烯和红没药烯的微生物代谢工程. 生物工程学报, 2018, 34(1): 24-33.
[25] 刘士琦, 荣兰新, 赵栢祥, 卢志慧, 赵 禹, 肖冬光, 于爱群*. 乳酸克鲁维酵母作为微生物细胞工厂的应用研究进展. 食品科学, 2022, 43(15): 357-366.
[26] 赵禹, 刘士琦, 李建，李圣龙, 赵雅坤, 肖冬光, 于爱群*. 解脂耶氏酵母作为微生物细胞工厂的应用研究进展. 食品科学, 2021, 42(19): 388-400.
[27] 赵禹, 赵雅坤, 刘士琦, 李建, 李圣龙, 肖冬光, 于爱群*. 非常规酵母的分子遗传学及合成生物学研究进展. 微生物学报, 2020, 60(8): 1574-1591.
[28] 于爱群, 石桐磊, 张飙, 邢来君, 李明春*. 低温和外源不饱和脂肪酸对高山被孢霉脂肪酸脱氢酶基因表达的影响, 微生物学报, 2012, 52(11): 1369-1377.
[29] 孔婧, 朱坤，刘士琦, 荣兰新, 肖冬光, 于爱群*. 代谢工程改造解脂耶氏酵母合成植物萜类化合物的研究进展. 微生物学通报, 2021, 48(4): 1302-1313.
[30] 于爱群*, 庞亚如, 胡智慧, 肖冬光. 平台化学品短链支链脂肪酸和短链支链醇的微生物代谢工程. 微生物学通报, 2018, 45(1): 173-180.
[31] 何思成, 张紫瑗, 韩雨晴, 苗琳, 张翠英, 于爱群*. 解脂耶氏酵母细胞工厂生产多不饱和脂肪酸的研究进展. 生物技术通报, 2024, 40(1): 72-85.
[32] 朱坤，孔婧, 荣兰新, 刘士琦, 肖冬光, 于爱群*. 代谢工程改造微生物合成单萜芳香产品的研究进展. 食品工业科技, 2021, 42(7): 390-398.
[33] 于爱群*, 马立娟, 郭学武, 董健, 肖冬光. 主题研讨模式在“合成生物学导论”课程中的应用. 高校生物学教学研究, 2019, 9(1): 30-34.
[34] 于爱群, 江贤章, 夏晓峰, 吴松刚, 黄建忠*. γ-亚麻酸产生菌Mucor sp. EIM-10的筛选及分子鉴定, 生物加工过程, 2009, 7(2): 74-78.
（2）发明专利：
[1] 于爱群，庞亚如，赵雅坤，张翠英，肖冬光. 一种产柠檬烯的解脂耶氏酵母及其构建方法与应用 (CN201810441360.3）.
[2] 于爱群，赵雅坤，李建，李圣龙，赵禹，朱坤，张翠英，肖冬光. 一种产红没药烯的解脂耶氏酵母及其构建方法与用途（CN201911169971.8）.
[3] 于爱群，李建，苗琳，荣兰新，赵禹，李圣龙，张翠英，肖冬光. 一种生产柠檬烯的解脂耶氏酵母工程菌及应用（ZL202011129990.0）.
[4] 于爱群，孔婧，苗琳，王淑慧，卢志慧，赵栢祥，肖冬光，张翠英. 一种香树脂醇合酶突变体及其应用（ZL202210011919.5）.
[5] 于爱群，荣兰新，卢志慧，王亚平，肖冬光，张翠英. 一种亚细胞区室化生产衣康酸的解脂耶氏酵母工程菌及应用（CN202210206191.1）.
[6] 于爱群，朱坤，赵栢祥，王亚平，张亚辉，肖冬光，张翠英. 一种利用解脂耶氏酵母线粒体途径定位合成α-红没药烯的方法（ZL202210343158.3）.
[7] 于爱群，赵栢祥，王亚平，张亚辉，张翠英，肖冬光. 一种生产红没药烯的区室化工程菌及其构建方法与应用（CN202310665745.9）.
获奖情况：
[1] 2020年度天津市食品科技创新奖一等奖，优质白酒酿造关键技术及其应用，排名第10（省部级）
联系方式：
办公地点：天津经济技术开发区第十三大街29号2号楼308室
邮政编码：300457
办公电话：022-60602723
传 真：022-60602298
Email：yuaiqun@tust.edu.cn
